The Curriculum

Every topic, mapped. Provisional.

The full Step 1 teaching plan, organised into five phases: Foundations, Organ Systems, Integration, Exam Prep, and Bonus. Search or filter to find any topic. Dates are provisional and subject to change.

Update: Based on recent feedback from Step 1 passed mentors, we are looking to substantially shorten the duration of the teaching series. We now aim to launch in mid-July. The curriculum below remains the same in content, but all dates are provisional and will be revised to reflect the new, more focused timeline.

Showing 365 of 365 days

Day	Phase	System	Topic	Subtopics
1	Foundations	Biochemistry	Course Introduction & Study Strategy	How to use this series, USMLE format, Oxford-to-USMLE bridge
2	Foundations	Biochemistry	DNA Structure & Replication	Replication machinery, origins, fidelity
3	Foundations	Biochemistry	Transcription & RNA Processing	Promoters, RNA pol, splicing, snRNPs
4	Foundations	Biochemistry	Translation & Post-translational Modification	Ribosomes, codons, chaperones, glycosylation
5	Foundations	Biochemistry	DNA Repair Mechanisms	BER, NER, MMR, NHEJ, HR — clinical correlates
6	Foundations	Biochemistry	Cell Cycle & Apoptosis	CDKs, cyclins, checkpoints, p53, Bcl-2
7	Foundations	Biochemistry	Oncogenes & Tumour Suppressors	Ras, Myc, Rb, APC, BRCA — mechanisms
8	Foundations	Biochemistry	Glycolysis & Gluconeogenesis	Regulation, enzyme deficiencies, Cori cycle
9	Foundations	Biochemistry	TCA Cycle & Oxidative Phosphorylation	Electron transport chain, ATP synthase, uncouplers
10	Foundations	Biochemistry	Fatty Acid Metabolism	Beta oxidation, ketogenesis, fatty acid synthesis
11	Foundations	Biochemistry	Amino Acid Metabolism	Urea cycle, phenylketonuria, maple syrup urine disease
12	Foundations	Biochemistry	Vitamins — Fat Soluble	A, D, E, K — deficiencies and toxicities
13	Foundations	Biochemistry	Vitamins — Water Soluble	B complex, C — Wernicke, pellagra, scurvy
14	Foundations	Biochemistry	Glycogen & Lysosomal Storage Diseases	Von Gierke, Pompe, Gaucher, Niemann-Pick, Tay-Sachs
15	Foundations	Genetics	Mendelian Inheritance	Autosomal dominant/recessive, X-linked, pedigree analysis
16	Foundations	Genetics	Chromosomal Disorders	Trisomies, deletions, translocations — Down, Turner, Klinefelter
17	Foundations	Genetics	Imprinting & Trinucleotide Repeats	Prader-Willi, Angelman, Fragile X, Huntington, myotonic dystrophy
18	Foundations	Genetics	Population Genetics	Hardy-Weinberg, carrier frequency, founder effect
19	Foundations	Genetics	Cell Signalling	Receptor types, second messengers, cAMP, IP3, RTKs
20	Foundations	Genetics	Cell Transport & Membranes	Ion channels, pumps, endocytosis, membrane potentials
21	Foundations	Genetics	Stem Cells & Development	Embryonic layers, neural crest, organogenesis
22	Foundations	Microbiology	Bacterial Structure & Classification	Gram positive/negative, cell wall, virulence factors
23	Foundations	Microbiology	Bacterial Genetics & Resistance	Conjugation, transformation, transduction, resistance mechanisms
24	Foundations	Microbiology	Viral Structure & Replication	DNA vs RNA viruses, enveloped vs non-enveloped, life cycle
25	Foundations	Microbiology	Fungal & Parasitic Overview	Morphology, opportunistic infections, antiparasitic drugs
26	Foundations	Microbiology	Sterilisation & Infection Control	Autoclave, antiseptics, hospital-acquired infections
27	Foundations	Immunology	Innate Immunity	Pattern recognition, complement, NK cells, inflammation
28	Foundations	Immunology	Adaptive Immunity Overview	T and B cell development, MHC, antigen presentation
29	Organ Systems	Cardiology	Cardiac Embryology	Heart tube formation, septation defects, neural crest contribution
30	Organ Systems	Cardiology	Cardiac Anatomy	Chambers, valves, coronary circulation, conduction system
31	Organ Systems	Cardiology	Cardiac Physiology — Action Potentials	Nodal vs ventricular, phases, ion channels
32	Organ Systems	Cardiology	Cardiac Physiology — Mechanics	Frank-Starling, preload, afterload, contractility, Starling curve
33	Organ Systems	Cardiology	ECG Interpretation	Intervals, axis, hypertrophy, systematic reading
34	Organ Systems	Cardiology	Congenital Heart Disease — Left to Right Shunts	ASD, VSD, PDA — pathophysiology and presentation
35	Organ Systems	Cardiology	Congenital Heart Disease — Right to Left Shunts	Tetralogy of Fallot, transposition, truncus arteriosus
36	Organ Systems	Cardiology	Ischaemic Heart Disease	Atherosclerosis, angina, ACS pathophysiology
37	Organ Systems	Cardiology	Myocardial Infarction	STEMI vs NSTEMI, timeline of changes, biomarkers
38	Organ Systems	Cardiology	MI Complications	Arrhythmias, free wall rupture, papillary muscle, Dressler
39	Organ Systems	Cardiology	Heart Failure	Systolic vs diastolic, left vs right, compensatory mechanisms
40	Organ Systems	Cardiology	Cardiomyopathies	Dilated, hypertrophic, restrictive — causes and echo findings
41	Organ Systems	Cardiology	Valvular Disease	Aortic stenosis, mitral regurgitation, murmur classification
42	Organ Systems	Cardiology	Pericardial Disease	Pericarditis, tamponade, constrictive pericarditis
43	Organ Systems	Cardiology	Arrhythmias — Bradycardia	Heart blocks, sick sinus syndrome, pacemaker indications
44	Organ Systems	Cardiology	Arrhythmias — Tachycardia	SVT, AF, VT, VF — mechanisms and management
45	Organ Systems	Cardiology	Hypertension	Primary vs secondary, end organ damage, hypertensive emergency
46	Organ Systems	Cardiology	Antihypertensives — ACEi and ARBs	Mechanism, side effects, contraindications, RAAS
47	Organ Systems	Cardiology	Antihypertensives — Beta Blockers & CCBs	Selectivity, heart failure use, dihydropyridines vs non
48	Organ Systems	Cardiology	Antiarrhythmics	Vaughan-Williams classification, amiodarone toxicity
49	Organ Systems	Cardiology	Heart Failure Pharmacology	Diuretics, digoxin, hydralazine, sacubitril-valsartan
50	Organ Systems	Cardiology	Lipid-Lowering Drugs	Statins, fibrates, ezetimibe, PCSK9 inhibitors
51	Organ Systems	Cardiology	Anticoagulants	Heparin, warfarin, DOACs — mechanism and reversal
52	Organ Systems	Cardiology	Antiplatelets	Aspirin, clopidogrel, GPIIb/IIIa inhibitors
53	Organ Systems	Cardiology	Shock	Cardiogenic, distributive, hypovolaemic, obstructive
54	Organ Systems	Cardiology	Vascular Disease	Aortic aneurysm, dissection, peripheral arterial disease
55	Organ Systems	Cardiology	Cardiology Pathology Review	High yield pathology slides and gross pathology
56	Organ Systems	Cardiology	Cardiology Cases & Integration	Clinical vignette practice — putting it all together
57	Organ Systems	Respiratory	Lung Embryology & Anatomy	Lung development stages, lobes, segments, pleura
58	Organ Systems	Respiratory	Respiratory Physiology — Volumes	TLC, FRC, RV, spirometry interpretation
59	Organ Systems	Respiratory	Ventilation-Perfusion	V/Q matching, zones of lung, V/Q mismatch vs shunt
60	Organ Systems	Respiratory	Gas Exchange & Transport	Oxygen dissociation curve, CO2 transport, Bohr effect
61	Organ Systems	Respiratory	Acid-Base Physiology	Henderson-Hasselbalch, compensation, ABG interpretation
62	Organ Systems	Respiratory	Obstructive Lung Disease — Asthma	Pathophysiology, triggers, management, status asthmaticus
63	Organ Systems	Respiratory	Obstructive Lung Disease — COPD	Emphysema vs chronic bronchitis, pink puffer vs blue bloater
64	Organ Systems	Respiratory	Restrictive Lung Disease	Intrinsic vs extrinsic, fibrosis, sarcoidosis
65	Organ Systems	Respiratory	Pneumoconioses	Asbestosis, silicosis, coal worker, berylliosis
66	Organ Systems	Respiratory	Pulmonary Hypertension	Primary vs secondary, Eisenmenger, treatment
67	Organ Systems	Respiratory	Pulmonary Embolism	Risk factors, Wells criteria, management, massive PE
68	Organ Systems	Respiratory	Pneumonia — Bacterial	CAP vs HAP, typical vs atypical, lobar vs broncho
69	Organ Systems	Respiratory	Pneumonia — Atypical & Special	Mycoplasma, Legionella, PCP, aspiration
70	Organ Systems	Respiratory	Tuberculosis	Primary vs reactivation, Ghon complex, miliary TB, treatment
71	Organ Systems	Respiratory	Lung Cancer	Types, locations, paraneoplastic syndromes, Pancoast
72	Organ Systems	Respiratory	Pleural Disease	Pleural effusion, pneumothorax, mesothelioma
73	Organ Systems	Respiratory	Sleep Disorders	OSA, central sleep apnoea, obesity hypoventilation
74	Organ Systems	Respiratory	Respiratory Infections — Viral	Influenza, RSV, COVID-19, ARDS
75	Organ Systems	Respiratory	Respiratory Pharmacology — Bronchodilators	Beta agonists, anticholinergics, theophylline
76	Organ Systems	Respiratory	Respiratory Pharmacology — Anti-inflammatory	Corticosteroids, leukotriene antagonists, biologics
77	Organ Systems	Respiratory	Respiratory Cases & Integration	Clinical vignette practice
78	Organ Systems	Renal	Renal Embryology & Anatomy	Pronephros, mesonephros, metanephros, horseshoe kidney
79	Organ Systems	Renal	Nephron Physiology — Filtration	GFR, Starling forces, autoregulation, creatinine clearance
80	Organ Systems	Renal	Nephron Physiology — Tubular Function	PCT, loop, DCT, collecting duct — reabsorption and secretion
81	Organ Systems	Renal	Water & Sodium Balance	ADH, aldosterone, osmolarity, hypo and hypernatraemia
82	Organ Systems	Renal	Potassium Balance	Hypo and hyperkalaemia — causes, ECG changes, treatment
83	Organ Systems	Renal	Acid-Base — Metabolic	Metabolic acidosis/alkalosis, anion gap, causes
84	Organ Systems	Renal	Acid-Base — Respiratory	Respiratory acidosis/alkalosis, compensation rules
85	Organ Systems	Renal	Acute Kidney Injury	Pre-renal, intrinsic, post-renal — FENa, BUN/Cr ratio
86	Organ Systems	Renal	Chronic Kidney Disease	Staging, complications, anaemia of CKD, renal osteodystrophy
87	Organ Systems	Renal	Glomerulonephritis — Nephritic	Post-strep, IgA nephropathy, RPGN, Goodpasture
88	Organ Systems	Renal	Glomerulonephritis — Nephrotic	Minimal change, FSGS, membranous, diabetic nephropathy
89	Organ Systems	Renal	Tubular & Interstitial Disease	ATN, AIN, Fanconi syndrome, renal tubular acidosis
90	Organ Systems	Renal	Renal Vascular Disease	Renal artery stenosis, thrombotic microangiopathy, HUS/TTP
91	Organ Systems	Renal	Urinary Tract Infections	Cystitis, pyelonephritis, organisms, recurrent UTI
92	Organ Systems	Renal	Renal Stones	Types, risk factors, presentation, management
93	Organ Systems	Renal	Renal Tumours	RCC, Wilms tumour, transitional cell carcinoma
94	Organ Systems	Renal	Diuretics	Loop, thiazide, potassium-sparing, carbonic anhydrase — sites of action
95	Organ Systems	Renal	Renal Pharmacology	ACEi in CKD, EPO, phosphate binders, dialysis principles
96	Organ Systems	Renal	Renal Cases & Integration	Clinical vignette practice
97	Organ Systems	Neurology	Neuro Embryology	Neural tube defects, brain development, holoprosencephaly
98	Organ Systems	Neurology	Neuroanatomy — Cerebral Cortex	Lobes, functional areas, lesion localisation
99	Organ Systems	Neurology	Neuroanatomy — Subcortical	Basal ganglia, thalamus, hypothalamus, limbic system
100	Organ Systems	Neurology	Neuroanatomy — Brainstem	Midbrain, pons, medulla — cranial nerve nuclei
101	Organ Systems	Neurology	Cranial Nerves	CN I-XII — functions, lesions, clinical testing
102	Organ Systems	Neurology	Spinal Cord Anatomy	Tracts, levels, spinal cord syndromes
103	Organ Systems	Neurology	Cerebrospinal Fluid & Ventricles	CSF production, flow, hydrocephalus, LP findings
104	Organ Systems	Neurology	Stroke — Ischaemic	Territories, lacunar infarcts, NIHSS, thrombolysis
105	Organ Systems	Neurology	Stroke — Haemorrhagic	ICH, SAH, epidural vs subdural haematoma
106	Organ Systems	Neurology	Dementia	Alzheimer, vascular, Lewy body, FTD — distinguishing features
107	Organ Systems	Neurology	Movement Disorders	Parkinson's, Huntington's, essential tremor, Wilson's
108	Organ Systems	Neurology	Epilepsy	Seizure classification, EEG, first-line treatment, status epilepticus
109	Organ Systems	Neurology	Headache Disorders	Migraine, cluster, tension, raised ICP
110	Organ Systems	Neurology	Multiple Sclerosis	Pathophysiology, McDonald criteria, types, treatment
111	Organ Systems	Neurology	Peripheral Neuropathy	Axonal vs demyelinating, Guillain-Barré, Charcot-Marie-Tooth
112	Organ Systems	Neurology	Neuromuscular Junction Disorders	Myasthenia gravis, Lambert-Eaton, botulism
113	Organ Systems	Neurology	CNS Infections	Meningitis, encephalitis, brain abscess, CSF analysis
114	Organ Systems	Neurology	CNS Tumours	Glioblastoma, meningioma, acoustic neuroma, metastases
115	Organ Systems	Neurology	Neuropharmacology — Anaesthetics	Local, general, neuromuscular blockers
116	Organ Systems	Neurology	Neuropharmacology — Antiepileptics	Mechanisms, teratogenicity, drug interactions
117	Organ Systems	Neurology	Neuropharmacology — Parkinson's & MS	Levodopa, dopamine agonists, interferons, natalizumab
118	Organ Systems	Neurology	Autonomic Nervous System	Sympathetic vs parasympathetic, pharmacological targets
119	Organ Systems	Neurology	Pain Pathways & Analgesics	Ascending pain, opioids, NSAIDs, neuropathic pain
120	Organ Systems	Neurology	Neurology Cases & Integration	Clinical vignette practice
121	Organ Systems	GI	GI Embryology	Gut tube formation, rotation, Meckel's diverticulum
122	Organ Systems	GI	Oesophagus	Achalasia, GERD, Barrett's, oesophageal cancer
123	Organ Systems	GI	Stomach — Physiology	Gastric acid, parietal cells, gastrin, intrinsic factor
124	Organ Systems	GI	Peptic Ulcer Disease	H. pylori, NSAIDs, Zollinger-Ellison, complications
125	Organ Systems	GI	Small Intestine — Absorption	Nutrients, vitamins, fat malabsorption, brush border enzymes
126	Organ Systems	GI	Malabsorption Syndromes	Coeliac disease, Crohn's, tropical sprue, Whipple's
127	Organ Systems	GI	Inflammatory Bowel Disease — Crohn's	Skip lesions, transmural, extraintestinal manifestations
128	Organ Systems	GI	Inflammatory Bowel Disease — UC	Continuous, mucosal, toxic megacolon, cancer risk
129	Organ Systems	GI	Colorectal Cancer	Adenoma-carcinoma sequence, FAP, Lynch, staging
130	Organ Systems	GI	GI Bleeding	Upper vs lower, causes, management priorities
131	Organ Systems	GI	Liver — Physiology	Bilirubin metabolism, liver function tests interpretation
132	Organ Systems	GI	Hepatitis — Viral	Hep A, B, C, D, E — transmission, serology, chronicity
133	Organ Systems	GI	Alcoholic Liver Disease	Fatty liver, hepatitis, cirrhosis — histology and biomarkers
134	Organ Systems	GI	Cirrhosis & Portal Hypertension	Complications — varices, ascites, HRS, SBP, HE
135	Organ Systems	GI	Liver Tumours	HCC, cholangiocarcinoma, metastases, haemangioma
136	Organ Systems	GI	Metabolic Liver Disease	NAFLD, haemochromatosis, Wilson's, alpha-1 antitrypsin
137	Organ Systems	GI	Gallbladder & Biliary	Cholelithiasis, cholecystitis, cholangitis, PSC, PBC
138	Organ Systems	GI	Pancreas	Acute vs chronic pancreatitis, pancreatic cancer, cysts
139	Organ Systems	GI	GI Pharmacology	PPIs, H2 blockers, antiemetics, laxatives, antidiarrhoeals
140	Organ Systems	GI	GI Cases & Integration	Clinical vignette practice
141	Organ Systems	Endocrinology	Hypothalamic-Pituitary Axis	Feedback loops, releasing hormones, portal circulation
142	Organ Systems	Endocrinology	Anterior Pituitary	GH, prolactin, TSH, ACTH, FSH, LH — disorders
143	Organ Systems	Endocrinology	Posterior Pituitary	ADH, oxytocin, diabetes insipidus, SIADH
144	Organ Systems	Endocrinology	Thyroid — Physiology	T3/T4 synthesis, transport, peripheral conversion, feedback
145	Organ Systems	Endocrinology	Hypothyroidism	Hashimoto's, iodine deficiency, iatrogenic, myxoedema coma
146	Organ Systems	Endocrinology	Hyperthyroidism	Graves', toxic nodule, thyroiditis, thyroid storm
147	Organ Systems	Endocrinology	Thyroid Cancer	Papillary, follicular, medullary, anaplastic — features
148	Organ Systems	Endocrinology	Adrenal Cortex — Physiology	Zona glomerulosa, fasciculata, reticularis — steroidogenesis
149	Organ Systems	Endocrinology	Glucocorticoid Biology	Cortisol synthesis, stress response, receptor signalling
150	Organ Systems	Endocrinology	Adrenal Insufficiency	Primary vs secondary, Addison's, adrenal crisis
151	Organ Systems	Endocrinology	Cushing's Syndrome	ACTH dependent vs independent, dexamethasone suppression
152	Organ Systems	Endocrinology	Adrenal Medulla & Phaeochromocytoma	Catecholamine synthesis, VMA, metanephrines
153	Organ Systems	Endocrinology	Congenital Adrenal Hyperplasia	21-hydroxylase deficiency, salt-wasting, virilisation
154	Organ Systems	Endocrinology	Diabetes Mellitus — Type 1	Autoimmune destruction, DKA, insulin types
155	Organ Systems	Endocrinology	Diabetes Mellitus — Type 2	Insulin resistance, metabolic syndrome, HHS
156	Organ Systems	Endocrinology	Diabetes Pharmacology	Metformin, sulfonylureas, GLP-1, SGLT2, insulin
157	Organ Systems	Endocrinology	Calcium & PTH	Hypo and hypercalcaemia, PTH, PTHrP, vitamin D
158	Organ Systems	Endocrinology	Parathyroid Disorders	Primary, secondary, tertiary hyperPTH, hypoparathyroidism
159	Organ Systems	Endocrinology	MEN Syndromes	MEN1, MEN2A, MEN2B — tumour associations
160	Organ Systems	Endocrinology	Endocrinology Cases & Integration	Clinical vignette practice
161	Organ Systems	Haematology	Haematopoiesis	Stem cells, lineages, growth factors, bone marrow
162	Organ Systems	Haematology	Anaemia — Overview & Iron Deficiency	Classification, indices, iron studies, iron deficiency anaemia
163	Organ Systems	Haematology	Anaemia — B12 & Folate	Megaloblastic anaemia, subacute combined degeneration
164	Organ Systems	Haematology	Haemolytic Anaemia	Intrinsic vs extrinsic, Coombs test, sickle cell, spherocytosis
165	Organ Systems	Haematology	Sickle Cell Disease	Pathophysiology, crises, complications, management
166	Organ Systems	Haematology	Thalassaemia	Alpha vs beta, genetics, transfusion dependency
167	Organ Systems	Haematology	Enzyme Deficiencies & RBC Membrane	G6PD, PK deficiency, hereditary spherocytosis, elliptocytosis
168	Organ Systems	Haematology	Platelet Disorders	ITP, TTP, HUS, thrombocytopenia — causes and management
169	Organ Systems	Haematology	Coagulation Cascade	Intrinsic vs extrinsic, PT vs aPTT, factor deficiencies
170	Organ Systems	Haematology	Coagulation Disorders	Haemophilia A and B, von Willebrand disease, DIC
171	Organ Systems	Haematology	Thrombophilia	Factor V Leiden, protein C/S deficiency, antiphospholipid
172	Organ Systems	Haematology	Leukaemia — ALL & CLL	Age predilection, markers, prognosis, Philadelphia chromosome
173	Organ Systems	Haematology	Leukaemia — AML & CML	FAB classification, Auer rods, BCR-ABL, imatinib
174	Organ Systems	Haematology	Lymphoma — Hodgkin's	Reed-Sternberg cells, subtypes, staging, EBV
175	Organ Systems	Haematology	Lymphoma — Non-Hodgkin's	Diffuse large B cell, Burkitt's, follicular, mantle cell
176	Organ Systems	Haematology	Multiple Myeloma	Plasma cell dyscrasia, CRAB criteria, M spike, treatment
177	Organ Systems	Haematology	Myeloproliferative Disorders	Polycythaemia vera, ET, myelofibrosis, JAK2
178	Organ Systems	Haematology	Cancer Biology	Hallmarks of cancer, oncogenesis, metastasis cascade
179	Organ Systems	Haematology	Cancer Pharmacology — Chemotherapy	Alkylating agents, antimetabolites, topoisomerase inhibitors
180	Organ Systems	Haematology	Cancer Pharmacology — Targeted & Immunotherapy	Tyrosine kinase inhibitors, checkpoint inhibitors, CAR-T
181	Organ Systems	Haematology	Haematology Cases & Integration	Clinical vignette practice
182	Organ Systems	MSK	Bone Physiology	Osteoblasts, osteoclasts, bone remodelling, calcium regulation
183	Organ Systems	MSK	Osteoporosis & Paget's Disease	DEXA, bisphosphonates, Paget's — pathophysiology
184	Organ Systems	MSK	Bone Tumours	Osteosarcoma, Ewing's, chondrosarcoma, giant cell tumour
185	Organ Systems	MSK	Rheumatoid Arthritis	Pathophysiology, extraarticular, anti-CCP, treatment
186	Organ Systems	MSK	Seronegative Spondyloarthropathies	Ankylosing spondylitis, psoriatic arthritis, reactive arthritis
187	Organ Systems	MSK	Crystal Arthropathies	Gout, pseudogout, urate metabolism, colchicine
188	Organ Systems	MSK	Osteoarthritis	Pathophysiology, joints affected, Heberden vs Bouchard nodes
189	Organ Systems	MSK	Systemic Lupus Erythematosus	Criteria, ANA, anti-dsDNA, lupus nephritis, drug-induced
190	Organ Systems	MSK	Myositis & Scleroderma	DM, PM, CREST syndrome, anti-Scl-70, anti-centromere
191	Organ Systems	MSK	Vasculitis — Large Vessel	GCA, Takayasu's — presentations and treatment
192	Organ Systems	MSK	Vasculitis — Small & Medium Vessel	GPA, MPA, EGPA, PAN, Kawasaki, Henoch-Schönlein
193	Organ Systems	MSK	MSK Pharmacology	DMARDs, biologics, NSAIDs, corticosteroids in rheum
194	Organ Systems	MSK	Muscle Physiology	Sarcomere, sliding filament, neuromuscular junction
195	Organ Systems	MSK	MSK Cases & Integration	Clinical vignette practice
196	Organ Systems	Dermatology	Skin Structure & Function	Epidermis layers, dermis, appendages, skin barrier
197	Organ Systems	Dermatology	Common Inflammatory Dermatoses	Psoriasis, eczema, contact dermatitis, seborrhoeic
198	Organ Systems	Dermatology	Blistering Disorders	Pemphigus vulgaris, bullous pemphigoid, dermatitis herpetiformis
199	Organ Systems	Dermatology	Skin Cancer	BCC, SCC, melanoma — ABCDE, risk factors, spread
200	Organ Systems	Dermatology	Infectious Dermatology	Cellulitis, impetigo, tinea, herpes zoster, SSSS
201	Organ Systems	Dermatology	Systemic Disease & Skin	Skin findings in diabetes, SLE, liver disease, sarcoid
202	Organ Systems	Dermatology	Dermatology Cases & Integration	Clinical vignette practice
203	Organ Systems	Reproductive	Reproductive Embryology	Genital development, Müllerian/Wolffian ducts, intersex
204	Organ Systems	Reproductive	Female Reproductive Physiology	Menstrual cycle, ovarian and uterine phases, hormones
205	Organ Systems	Reproductive	Male Reproductive Physiology	Spermatogenesis, testosterone, FSH/LH axis
206	Organ Systems	Reproductive	Contraception & Infertility	OCP mechanism, IUD, emergency contraception, infertility workup
207	Organ Systems	Reproductive	STIs	Gonorrhoea, chlamydia, syphilis, herpes, HPV, HIV
208	Organ Systems	Reproductive	Normal Pregnancy & Obstetrics	Physiological changes, prenatal screening, labour
209	Organ Systems	Reproductive	Obstetric Complications	Pre-eclampsia, eclampsia, placenta praevia, abruption
210	Organ Systems	Reproductive	Gynaecological Pathology	Endometriosis, fibroids, PCOS, ovarian cysts
211	Organ Systems	Reproductive	Gynaecological Cancer	Cervical, endometrial, ovarian cancer — risk factors and screening
212	Organ Systems	Reproductive	Breast Pathology	Fibrocystic changes, fibroadenoma, breast cancer — types
213	Organ Systems	Reproductive	Reproductive Pharmacology	Oxytocin, tocolytics, fertility drugs, antiandrogens
214	Organ Systems	Reproductive	Reproductive Cases & Integration	Clinical vignette practice
215	Organ Systems	Psychiatry	Psychiatric Epidemiology & DSM	Prevalence, diagnostic framework, biopsychosocial model
216	Organ Systems	Psychiatry	Psychotic Disorders	Schizophrenia — positive/negative symptoms, dopamine hypothesis
217	Organ Systems	Psychiatry	Mood Disorders — Depression	MDD, dysthymia, postpartum, atypical features
218	Organ Systems	Psychiatry	Mood Disorders — Bipolar	Bipolar I vs II, cyclothymia, rapid cycling
219	Organ Systems	Psychiatry	Anxiety Disorders	GAD, panic disorder, phobias, PTSD, OCD
220	Organ Systems	Psychiatry	Personality Disorders	Clusters A, B, C — key features for USMLE
221	Organ Systems	Psychiatry	Somatoform Disorders	Somatic symptom disorder, conversion, factitious, malingering
222	Organ Systems	Psychiatry	Eating Disorders	Anorexia vs bulimia — complications and medical management
223	Organ Systems	Psychiatry	Substance Use Disorders	Alcohol, opioids, stimulants — intoxication, withdrawal, treatment
224	Organ Systems	Psychiatry	Child & Developmental Psychiatry	ADHD, autism, conduct disorder, childhood depression
225	Organ Systems	Psychiatry	Antidepressants	SSRIs, SNRIs, TCAs, MAOIs — mechanisms and side effects
226	Organ Systems	Psychiatry	Antipsychotics	Typical vs atypical, EPS, NMS, metabolic syndrome
227	Organ Systems	Psychiatry	Mood Stabilisers & Anxiolytics	Lithium toxicity, valproate, benzodiazepines
228	Organ Systems	Psychiatry	Psychiatry Cases & Integration	Clinical vignette practice
229	Organ Systems	Infectious Disease	Gram Positive Cocci	Staph aureus, strep pneumo, strep pyogenes — virulence and disease
230	Organ Systems	Infectious Disease	Gram Negative Rods — Enteric	E. coli, Salmonella, Shigella, Campylobacter, H. pylori
231	Organ Systems	Infectious Disease	Gram Negative Rods — Respiratory	Haemophilus, Klebsiella, Pseudomonas, Legionella, Bordetella
232	Organ Systems	Infectious Disease	Anaerobes & Spirochaetes	Clostridium, Bacteroides, Treponema, Leptospira, Borrelia
233	Organ Systems	Infectious Disease	Intracellular Organisms	Rickettsia, Chlamydia, Mycoplasma, Coxiella — atypical pneumonia
234	Organ Systems	Infectious Disease	Fungi	Candida, Aspergillus, Cryptococcus, Histoplasma, Coccidioides
235	Organ Systems	Infectious Disease	Parasites — Protozoa	Malaria, Toxoplasma, Giardia, Cryptosporidium, Entamoeba
236	Organ Systems	Infectious Disease	Parasites — Helminths	Roundworms, tapeworms, flukes — key species
237	Organ Systems	Infectious Disease	HIV & AIDS	Life cycle, CD4 staging, opportunistic infections, ART
238	Organ Systems	Infectious Disease	DNA Viruses	Herpes family, adenovirus, parvovirus, HPV, HBV
239	Organ Systems	Infectious Disease	RNA Viruses	Influenza, HIV, measles, mumps, rubella, rabies, Ebola
240	Organ Systems	Infectious Disease	Antibiotics — Cell Wall	Penicillins, cephalosporins, carbapenems, vancomycin
241	Organ Systems	Infectious Disease	Antibiotics — Protein Synthesis	Aminoglycosides, macrolides, tetracyclines, chloramphenicol
242	Organ Systems	Infectious Disease	Antivirals, Antifungals & Antiparasitics	Aciclovir, oseltamivir, azoles, amphotericin, chloroquine
243	Organ Systems	Infectious Disease	Sepsis & Bacteraemia	SIRS criteria, source control, empirical antibiotics
244	Organ Systems	Infectious Disease	Infectious Disease Cases	Clinical vignette practice
245	Organ Systems	Immunology	T Cell Biology	CD4 vs CD8, Th1/Th2/Th17/Treg, activation, tolerance
246	Organ Systems	Immunology	B Cell Biology & Antibodies	B cell activation, class switching, antibody types
247	Organ Systems	Immunology	Complement System	Classical, lectin, alternative pathways — C3, C5, MAC
248	Organ Systems	Immunology	Primary Immunodeficiencies — B Cell	Bruton's, common variable, selective IgA deficiency
249	Organ Systems	Immunology	Primary Immunodeficiencies — T Cell & Combined	DiGeorge, SCID, Wiskott-Aldrich, ataxia telangiectasia
250	Organ Systems	Immunology	Hypersensitivity Reactions	Type I-IV, mechanisms, clinical examples
251	Organ Systems	Immunology	Transplant Immunology	HLA matching, rejection types, graft vs host disease
252	Organ Systems	Immunology	Immunosuppressants	Ciclosporin, tacrolimus, azathioprine, mycophenolate, biologics
253	Organ Systems	Immunology	Vaccines	Live attenuated vs killed, mRNA, schedule, contraindications
254	Organ Systems	Immunology	Immunology Cases & Integration	Clinical vignette practice
255	Integration	Biostatistics	Study Design	RCT, cohort, case-control, cross-sectional — strengths and biases
256	Integration	Biostatistics	Bias & Confounding	Selection, recall, lead time bias, confounders, randomisation
257	Integration	Biostatistics	Statistical Tests	t-test, chi-squared, ANOVA, regression — when to use which
258	Integration	Biostatistics	Sensitivity, Specificity & Predictive Values	2x2 table, ROC curves, likelihood ratios
259	Integration	Biostatistics	Screening & Prevention	Primary, secondary, tertiary prevention, NNT, NNH
260	Integration	Biostatistics	Epidemiology	Incidence vs prevalence, mortality measures, outbreak investigation
261	Integration	Biostatistics	Biostatistics Cases & Integration	Practice calculations and vignettes
262	Integration	Ethics	Medical Ethics Principles	Autonomy, beneficence, non-maleficence, justice
263	Integration	Ethics	Informed Consent	Capacity, competence, surrogate decision making
264	Integration	Ethics	Confidentiality & Disclosure	Exceptions, duty to warn, mandatory reporting
265	Integration	Ethics	End of Life Ethics	DNR, withdrawal of care, euthanasia vs assisted dying
266	Integration	Ethics	Research Ethics	Tuskegee, Helsinki, IRB, equipoise
267	Integration	Pharmacology	Pharmacokinetics	ADME, volume of distribution, half-life, bioavailability
268	Integration	Pharmacology	Pharmacodynamics	Receptor types, agonism, antagonism, dose-response curves
269	Integration	Pharmacology	Autonomic Pharmacology	Adrenergic and cholinergic drugs — clinical applications
270	Integration	Pharmacology	High Yield Drug Toxicities	Aminoglycosides, cisplatin, methotrexate, amiodarone
271	Integration	Pharmacology	Drug Interactions	CYP450 inducers and inhibitors, warfarin interactions
272	Integration	Pharmacology	High Yield Antidotes	N-acetylcysteine, naloxone, atropine, flumazenil
273	Integration	Pharmacology	Pharmacology Cases	Clinical vignette practice — drug identification
274	Integration	Pathology	Cell Injury & Death	Necrosis types, apoptosis, ischaemia, free radicals
275	Integration	Pathology	Inflammation	Acute vs chronic, granulomas, wound healing
276	Integration	Pathology	Neoplasia	Benign vs malignant, invasion, metastasis, tumour markers
277	Integration	Pathology	Haemodynamics	Oedema, hyperaemia, thrombosis, embolism, infarction
278	Integration	Pathology	Genetic & Congenital Pathology	Chromosomal, single gene, multifactorial disorders
279	Integration	Pathology	Environmental & Nutritional Pathology	Toxins, radiation, nutritional deficiencies
280	Integration	Pathology	Pathology Integration Review	Cross-system pathology cases
281	Exam Prep	Integration	Complex Cardio-Renal Cases	Cardiorenal syndrome, diuretic resistance
282	Exam Prep	Integration	Neuro-Psych Integration	Organic vs psychiatric, delirium vs dementia vs depression
283	Exam Prep	Integration	Endocrine-Renal Cases	Diabetes and kidney, hyperaldosteronism, renal tubular syndromes
284	Exam Prep	Integration	Haem-Onc Complex Cases	Paraneoplastic syndromes, tumour lysis, hypercoagulability
285	Exam Prep	Integration	GI-Liver-Pancreas Cases	Acute abdomen, jaundice workup, hepatorenal syndrome
286	Exam Prep	Integration	Immunology-Infection Cases	Immunocompromised host, transplant infections
287	Exam Prep	Integration	Reproductive-Endocrine Cases	PCOS, thyroid in pregnancy, gestational diabetes
288	Exam Prep	Integration	Respiratory-Cardiac Cases	Cor pulmonale, PE mimicking MI, respiratory failure
289	Exam Prep	Integration	MSK-Neuro Cases	Motor neuron disease, myopathy vs neuropathy
290	Exam Prep	Integration	Dermatology-Systemic Cases	Rashes in systemic disease, drug reactions
291	Exam Prep	Pathology	High Yield Histology — Cardio & Respiratory	MI, cardiomyopathy, pneumonia, fibrosis slides
292	Exam Prep	Pathology	High Yield Histology — GI & Liver	Cirrhosis, IBD, colon cancer, hepatitis slides
293	Exam Prep	Pathology	High Yield Histology — Renal & Endocrine	Glomerulonephritis, RCC, thyroid, adrenal slides
294	Exam Prep	Pathology	High Yield Histology — Haem & Neuro	Leukaemia, lymphoma, glioma, MS slides
295	Exam Prep	Pathology	High Yield Radiology	CXR, CT findings, X-ray patterns for USMLE
296	Exam Prep	Pathology	High Yield ECG Review	Most tested ECG patterns — STEMI, blocks, arrhythmias
297	Exam Prep	Pathology	High Yield Lab Values	Electrolyte patterns, anaemia workup, LFTs, coagulation
298	Exam Prep	Review	Rapid Fire — Biochemistry	Highest yield facts, classic vignettes
299	Exam Prep	Review	Rapid Fire — Microbiology	Organisms, virulence, drug of choice
300	Exam Prep	Review	Rapid Fire — Cardiology	Classic presentations, drugs, ECG findings
301	Exam Prep	Review	Rapid Fire — Respiratory	Classic presentations, PFTs, drugs
302	Exam Prep	Review	Rapid Fire — Renal	Electrolytes, acid-base, drugs
303	Exam Prep	Review	Rapid Fire — Neurology	Localisation, strokes, drugs
304	Exam Prep	Review	Rapid Fire — GI	Classic cases, liver disease, cancer
305	Exam Prep	Review	Rapid Fire — Endocrinology	Hormones, feedback loops, drugs
306	Exam Prep	Review	Rapid Fire — Haematology	Anaemia, coagulation, cancers
307	Exam Prep	Review	Rapid Fire — MSK & Derm	Joint diseases, rashes, drugs
308	Exam Prep	Review	Rapid Fire — Psychiatry	Disorders, drugs, ethics
309	Exam Prep	Review	Rapid Fire — Infectious Disease	Organisms, antibiotics, HIV
310	Exam Prep	Review	Rapid Fire — Immunology	Deficiencies, hypersensitivity, transplant
311	Exam Prep	Review	Rapid Fire — Pharmacology	Mechanisms, toxicities, antidotes
312	Exam Prep	Bridge	UK vs US Medical Education	GMC vs USMLE, BM BCh vs MD, training pathways
313	Exam Prep	Bridge	IMG Application Strategy	ERAS, USMLE scores, research, LORs, visa
314	Exam Prep	Bridge	Step 1 Exam Strategy	Timing, question approach, educated guessing
315	Exam Prep	Bridge	Step 2 CK Preview	How Step 2 differs, clinical vignettes, preparation timeline
316	Exam Prep	Bridge	Resources Review	First Aid, UWorld, Anki, Sketchy, Pathoma — how to use each
317	Exam Prep	Final Review	Cardiology Final Review	Most tested topics, classic mistakes
318	Exam Prep	Final Review	Respiratory Final Review	Most tested topics, classic mistakes
319	Exam Prep	Final Review	Renal Final Review	Most tested topics, classic mistakes
320	Exam Prep	Final Review	Neurology Final Review	Most tested topics, classic mistakes
321	Exam Prep	Final Review	GI Final Review	Most tested topics, classic mistakes
322	Exam Prep	Final Review	Endocrinology Final Review	Most tested topics, classic mistakes
323	Exam Prep	Final Review	Haematology Final Review	Most tested topics, classic mistakes
324	Exam Prep	Final Review	MSK Final Review	Most tested topics, classic mistakes
325	Exam Prep	Final Review	Psychiatry Final Review	Most tested topics, classic mistakes
326	Exam Prep	Final Review	ID & Immunology Final Review	Most tested topics, classic mistakes
327	Exam Prep	Final Review	Biochemistry & Genetics Final Review	Most tested topics, classic mistakes
328	Exam Prep	Final Review	Pharmacology Final Review	Most tested topics, classic mistakes
329	Exam Prep	Final Review	Biostatistics & Ethics Final Review	Most tested topics, classic mistakes
330	Exam Prep	Final Review	NBME Practice Exam Walkthrough	Live question analysis and strategy
331	Bonus	Community	Q&A — Biochemistry	Audience questions answered live
332	Bonus	Community	Q&A — Cardiology	Audience questions answered live
333	Bonus	Community	Q&A — Neurology	Audience questions answered live
334	Bonus	Community	Q&A — Renal & Endocrine	Audience questions answered live
335	Bonus	Community	Q&A — GI & Hepatology	Audience questions answered live
336	Bonus	Community	Q&A — Haematology & Oncology	Audience questions answered live
337	Bonus	Community	Q&A — ID & Immunology	Audience questions answered live
338	Bonus	Community	Q&A — Psychiatry & Ethics	Audience questions answered live
339	Bonus	Community	Q&A — Pharmacology	Audience questions answered live
340	Bonus	Community	Q&A — Biostatistics	Audience questions answered live
341	Bonus	Special	Interview — US Residency Applicant	Real IMG who matched at a top US programme
342	Bonus	Special	Interview — Mayo Clinic Physician	What they look for in IMG applicants
343	Bonus	Special	Interview — Step 1 High Scorer	260+ scorer shares their strategy
344	Bonus	Special	Oxford Medicine Explained	FHS, BM BCh, how it compares to US MD
345	Bonus	Special	UK Clinical Years Survival Guide	How to balance USMLE prep with UK clinical training
346	Bonus	Special	MyUSMLE Community Showcase	Best student questions, community highlights
347	Bonus	Special	Medtech & Clinical Medicine	How clinical knowledge drives innovation
348	Bonus	Special	Research for IMG Applicants	How to get research as a UK student
349	Bonus	Special	Mental Health in Medicine	Burnout, wellbeing, sustainable study
350	Bonus	Special	Step 2 CK Preview — Medicine	Introduction to Step 2 approach
351	Bonus	Special	Step 2 CK Preview — Surgery	Surgical principles for Step 2
352	Bonus	Special	Step 2 CK Preview — Paediatrics	Paediatric medicine for Step 2
353	Bonus	Special	Step 2 CK Preview — OB/GYN	Obstetrics for Step 2
354	Bonus	Special	Step 2 CK Preview — Psychiatry	Psychiatry on Step 2 vs Step 1
355	Bonus	Special	Step 2 CK Preview — Emergency Medicine	EM approach for Step 2
356	Bonus	Special	US Residency Application Deep Dive — ERAS	Completing ERAS as an IMG
357	Bonus	Special	Personal Statement Workshop	Crafting a compelling IMG personal statement
358	Bonus	Special	Letters of Recommendation Guide	Who to ask, how to ask, what makes a great LOR
359	Bonus	Special	Interview Preparation	US residency interview common questions
360	Bonus	Special	Match Day Explained	NRMP algorithm, ranking strategies
361	Bonus	Special	Series Reflection — Year 1	What we learned, what worked, what's next
362	Bonus	Special	MyUSMLE Future Plans	Step 2 series, community growth, partnerships
363	Bonus	Special	Thank You & Community	Celebrating the journey together
364	Bonus	Special	Final Exam Pep Talk	Motivation and mindset for exam day
365	Bonus	Special	Day 365 — What Comes Next	Step 2, residency, the future of MyUSMLE

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