MMyUSMLEA MyUCAT Initiative
The Curriculum

365 days. Every topic, mapped.

The full Step 1 teaching plan, organised into five phases: Foundations, Organ Systems, Integration, Exam Prep, and Bonus. Search or filter to find any topic.

Showing 365 of 365 days
DayDatePhaseSystemTopicSubtopics
101 Jul 2026FoundationsBiochemistryCourse Introduction & Study StrategyHow to use this series, USMLE format, Oxford-to-USMLE bridge
202 Jul 2026FoundationsBiochemistryDNA Structure & ReplicationReplication machinery, origins, fidelity
303 Jul 2026FoundationsBiochemistryTranscription & RNA ProcessingPromoters, RNA pol, splicing, snRNPs
404 Jul 2026FoundationsBiochemistryTranslation & Post-translational ModificationRibosomes, codons, chaperones, glycosylation
505 Jul 2026FoundationsBiochemistryDNA Repair MechanismsBER, NER, MMR, NHEJ, HR — clinical correlates
606 Jul 2026FoundationsBiochemistryCell Cycle & ApoptosisCDKs, cyclins, checkpoints, p53, Bcl-2
707 Jul 2026FoundationsBiochemistryOncogenes & Tumour SuppressorsRas, Myc, Rb, APC, BRCA — mechanisms
808 Jul 2026FoundationsBiochemistryGlycolysis & GluconeogenesisRegulation, enzyme deficiencies, Cori cycle
909 Jul 2026FoundationsBiochemistryTCA Cycle & Oxidative PhosphorylationElectron transport chain, ATP synthase, uncouplers
1010 Jul 2026FoundationsBiochemistryFatty Acid MetabolismBeta oxidation, ketogenesis, fatty acid synthesis
1111 Jul 2026FoundationsBiochemistryAmino Acid MetabolismUrea cycle, phenylketonuria, maple syrup urine disease
1212 Jul 2026FoundationsBiochemistryVitamins — Fat SolubleA, D, E, K — deficiencies and toxicities
1313 Jul 2026FoundationsBiochemistryVitamins — Water SolubleB complex, C — Wernicke, pellagra, scurvy
1414 Jul 2026FoundationsBiochemistryGlycogen & Lysosomal Storage DiseasesVon Gierke, Pompe, Gaucher, Niemann-Pick, Tay-Sachs
1515 Jul 2026FoundationsGeneticsMendelian InheritanceAutosomal dominant/recessive, X-linked, pedigree analysis
1616 Jul 2026FoundationsGeneticsChromosomal DisordersTrisomies, deletions, translocations — Down, Turner, Klinefelter
1717 Jul 2026FoundationsGeneticsImprinting & Trinucleotide RepeatsPrader-Willi, Angelman, Fragile X, Huntington, myotonic dystrophy
1818 Jul 2026FoundationsGeneticsPopulation GeneticsHardy-Weinberg, carrier frequency, founder effect
1919 Jul 2026FoundationsGeneticsCell SignallingReceptor types, second messengers, cAMP, IP3, RTKs
2020 Jul 2026FoundationsGeneticsCell Transport & MembranesIon channels, pumps, endocytosis, membrane potentials
2121 Jul 2026FoundationsGeneticsStem Cells & DevelopmentEmbryonic layers, neural crest, organogenesis
2222 Jul 2026FoundationsMicrobiologyBacterial Structure & ClassificationGram positive/negative, cell wall, virulence factors
2323 Jul 2026FoundationsMicrobiologyBacterial Genetics & ResistanceConjugation, transformation, transduction, resistance mechanisms
2424 Jul 2026FoundationsMicrobiologyViral Structure & ReplicationDNA vs RNA viruses, enveloped vs non-enveloped, life cycle
2525 Jul 2026FoundationsMicrobiologyFungal & Parasitic OverviewMorphology, opportunistic infections, antiparasitic drugs
2626 Jul 2026FoundationsMicrobiologySterilisation & Infection ControlAutoclave, antiseptics, hospital-acquired infections
2727 Jul 2026FoundationsImmunologyInnate ImmunityPattern recognition, complement, NK cells, inflammation
2828 Jul 2026FoundationsImmunologyAdaptive Immunity OverviewT and B cell development, MHC, antigen presentation
2929 Jul 2026Organ SystemsCardiologyCardiac EmbryologyHeart tube formation, septation defects, neural crest contribution
3030 Jul 2026Organ SystemsCardiologyCardiac AnatomyChambers, valves, coronary circulation, conduction system
3131 Jul 2026Organ SystemsCardiologyCardiac Physiology — Action PotentialsNodal vs ventricular, phases, ion channels
3201 Aug 2026Organ SystemsCardiologyCardiac Physiology — MechanicsFrank-Starling, preload, afterload, contractility, Starling curve
3302 Aug 2026Organ SystemsCardiologyECG InterpretationIntervals, axis, hypertrophy, systematic reading
3403 Aug 2026Organ SystemsCardiologyCongenital Heart Disease — Left to Right ShuntsASD, VSD, PDA — pathophysiology and presentation
3504 Aug 2026Organ SystemsCardiologyCongenital Heart Disease — Right to Left ShuntsTetralogy of Fallot, transposition, truncus arteriosus
3605 Aug 2026Organ SystemsCardiologyIschaemic Heart DiseaseAtherosclerosis, angina, ACS pathophysiology
3706 Aug 2026Organ SystemsCardiologyMyocardial InfarctionSTEMI vs NSTEMI, timeline of changes, biomarkers
3807 Aug 2026Organ SystemsCardiologyMI ComplicationsArrhythmias, free wall rupture, papillary muscle, Dressler
3908 Aug 2026Organ SystemsCardiologyHeart FailureSystolic vs diastolic, left vs right, compensatory mechanisms
4009 Aug 2026Organ SystemsCardiologyCardiomyopathiesDilated, hypertrophic, restrictive — causes and echo findings
4110 Aug 2026Organ SystemsCardiologyValvular DiseaseAortic stenosis, mitral regurgitation, murmur classification
4211 Aug 2026Organ SystemsCardiologyPericardial DiseasePericarditis, tamponade, constrictive pericarditis
4312 Aug 2026Organ SystemsCardiologyArrhythmias — BradycardiaHeart blocks, sick sinus syndrome, pacemaker indications
4413 Aug 2026Organ SystemsCardiologyArrhythmias — TachycardiaSVT, AF, VT, VF — mechanisms and management
4514 Aug 2026Organ SystemsCardiologyHypertensionPrimary vs secondary, end organ damage, hypertensive emergency
4615 Aug 2026Organ SystemsCardiologyAntihypertensives — ACEi and ARBsMechanism, side effects, contraindications, RAAS
4716 Aug 2026Organ SystemsCardiologyAntihypertensives — Beta Blockers & CCBsSelectivity, heart failure use, dihydropyridines vs non
4817 Aug 2026Organ SystemsCardiologyAntiarrhythmicsVaughan-Williams classification, amiodarone toxicity
4918 Aug 2026Organ SystemsCardiologyHeart Failure PharmacologyDiuretics, digoxin, hydralazine, sacubitril-valsartan
5019 Aug 2026Organ SystemsCardiologyLipid-Lowering DrugsStatins, fibrates, ezetimibe, PCSK9 inhibitors
5120 Aug 2026Organ SystemsCardiologyAnticoagulantsHeparin, warfarin, DOACs — mechanism and reversal
5221 Aug 2026Organ SystemsCardiologyAntiplateletsAspirin, clopidogrel, GPIIb/IIIa inhibitors
5322 Aug 2026Organ SystemsCardiologyShockCardiogenic, distributive, hypovolaemic, obstructive
5423 Aug 2026Organ SystemsCardiologyVascular DiseaseAortic aneurysm, dissection, peripheral arterial disease
5524 Aug 2026Organ SystemsCardiologyCardiology Pathology ReviewHigh yield pathology slides and gross pathology
5625 Aug 2026Organ SystemsCardiologyCardiology Cases & IntegrationClinical vignette practice — putting it all together
5726 Aug 2026Organ SystemsRespiratoryLung Embryology & AnatomyLung development stages, lobes, segments, pleura
5827 Aug 2026Organ SystemsRespiratoryRespiratory Physiology — VolumesTLC, FRC, RV, spirometry interpretation
5928 Aug 2026Organ SystemsRespiratoryVentilation-PerfusionV/Q matching, zones of lung, V/Q mismatch vs shunt
6029 Aug 2026Organ SystemsRespiratoryGas Exchange & TransportOxygen dissociation curve, CO2 transport, Bohr effect
6130 Aug 2026Organ SystemsRespiratoryAcid-Base PhysiologyHenderson-Hasselbalch, compensation, ABG interpretation
6231 Aug 2026Organ SystemsRespiratoryObstructive Lung Disease — AsthmaPathophysiology, triggers, management, status asthmaticus
6301 Sept 2026Organ SystemsRespiratoryObstructive Lung Disease — COPDEmphysema vs chronic bronchitis, pink puffer vs blue bloater
6402 Sept 2026Organ SystemsRespiratoryRestrictive Lung DiseaseIntrinsic vs extrinsic, fibrosis, sarcoidosis
6503 Sept 2026Organ SystemsRespiratoryPneumoconiosesAsbestosis, silicosis, coal worker, berylliosis
6604 Sept 2026Organ SystemsRespiratoryPulmonary HypertensionPrimary vs secondary, Eisenmenger, treatment
6705 Sept 2026Organ SystemsRespiratoryPulmonary EmbolismRisk factors, Wells criteria, management, massive PE
6806 Sept 2026Organ SystemsRespiratoryPneumonia — BacterialCAP vs HAP, typical vs atypical, lobar vs broncho
6907 Sept 2026Organ SystemsRespiratoryPneumonia — Atypical & SpecialMycoplasma, Legionella, PCP, aspiration
7008 Sept 2026Organ SystemsRespiratoryTuberculosisPrimary vs reactivation, Ghon complex, miliary TB, treatment
7109 Sept 2026Organ SystemsRespiratoryLung CancerTypes, locations, paraneoplastic syndromes, Pancoast
7210 Sept 2026Organ SystemsRespiratoryPleural DiseasePleural effusion, pneumothorax, mesothelioma
7311 Sept 2026Organ SystemsRespiratorySleep DisordersOSA, central sleep apnoea, obesity hypoventilation
7412 Sept 2026Organ SystemsRespiratoryRespiratory Infections — ViralInfluenza, RSV, COVID-19, ARDS
7513 Sept 2026Organ SystemsRespiratoryRespiratory Pharmacology — BronchodilatorsBeta agonists, anticholinergics, theophylline
7614 Sept 2026Organ SystemsRespiratoryRespiratory Pharmacology — Anti-inflammatoryCorticosteroids, leukotriene antagonists, biologics
7715 Sept 2026Organ SystemsRespiratoryRespiratory Cases & IntegrationClinical vignette practice
7816 Sept 2026Organ SystemsRenalRenal Embryology & AnatomyPronephros, mesonephros, metanephros, horseshoe kidney
7917 Sept 2026Organ SystemsRenalNephron Physiology — FiltrationGFR, Starling forces, autoregulation, creatinine clearance
8018 Sept 2026Organ SystemsRenalNephron Physiology — Tubular FunctionPCT, loop, DCT, collecting duct — reabsorption and secretion
8119 Sept 2026Organ SystemsRenalWater & Sodium BalanceADH, aldosterone, osmolarity, hypo and hypernatraemia
8220 Sept 2026Organ SystemsRenalPotassium BalanceHypo and hyperkalaemia — causes, ECG changes, treatment
8321 Sept 2026Organ SystemsRenalAcid-Base — MetabolicMetabolic acidosis/alkalosis, anion gap, causes
8422 Sept 2026Organ SystemsRenalAcid-Base — RespiratoryRespiratory acidosis/alkalosis, compensation rules
8523 Sept 2026Organ SystemsRenalAcute Kidney InjuryPre-renal, intrinsic, post-renal — FENa, BUN/Cr ratio
8624 Sept 2026Organ SystemsRenalChronic Kidney DiseaseStaging, complications, anaemia of CKD, renal osteodystrophy
8725 Sept 2026Organ SystemsRenalGlomerulonephritis — NephriticPost-strep, IgA nephropathy, RPGN, Goodpasture
8826 Sept 2026Organ SystemsRenalGlomerulonephritis — NephroticMinimal change, FSGS, membranous, diabetic nephropathy
8927 Sept 2026Organ SystemsRenalTubular & Interstitial DiseaseATN, AIN, Fanconi syndrome, renal tubular acidosis
9028 Sept 2026Organ SystemsRenalRenal Vascular DiseaseRenal artery stenosis, thrombotic microangiopathy, HUS/TTP
9129 Sept 2026Organ SystemsRenalUrinary Tract InfectionsCystitis, pyelonephritis, organisms, recurrent UTI
9230 Sept 2026Organ SystemsRenalRenal StonesTypes, risk factors, presentation, management
9301 Oct 2026Organ SystemsRenalRenal TumoursRCC, Wilms tumour, transitional cell carcinoma
9402 Oct 2026Organ SystemsRenalDiureticsLoop, thiazide, potassium-sparing, carbonic anhydrase — sites of action
9503 Oct 2026Organ SystemsRenalRenal PharmacologyACEi in CKD, EPO, phosphate binders, dialysis principles
9604 Oct 2026Organ SystemsRenalRenal Cases & IntegrationClinical vignette practice
9705 Oct 2026Organ SystemsNeurologyNeuro EmbryologyNeural tube defects, brain development, holoprosencephaly
9806 Oct 2026Organ SystemsNeurologyNeuroanatomy — Cerebral CortexLobes, functional areas, lesion localisation
9907 Oct 2026Organ SystemsNeurologyNeuroanatomy — SubcorticalBasal ganglia, thalamus, hypothalamus, limbic system
10008 Oct 2026Organ SystemsNeurologyNeuroanatomy — BrainstemMidbrain, pons, medulla — cranial nerve nuclei
10109 Oct 2026Organ SystemsNeurologyCranial NervesCN I-XII — functions, lesions, clinical testing
10210 Oct 2026Organ SystemsNeurologySpinal Cord AnatomyTracts, levels, spinal cord syndromes
10311 Oct 2026Organ SystemsNeurologyCerebrospinal Fluid & VentriclesCSF production, flow, hydrocephalus, LP findings
10412 Oct 2026Organ SystemsNeurologyStroke — IschaemicTerritories, lacunar infarcts, NIHSS, thrombolysis
10513 Oct 2026Organ SystemsNeurologyStroke — HaemorrhagicICH, SAH, epidural vs subdural haematoma
10614 Oct 2026Organ SystemsNeurologyDementiaAlzheimer, vascular, Lewy body, FTD — distinguishing features
10715 Oct 2026Organ SystemsNeurologyMovement DisordersParkinson's, Huntington's, essential tremor, Wilson's
10816 Oct 2026Organ SystemsNeurologyEpilepsySeizure classification, EEG, first-line treatment, status epilepticus
10917 Oct 2026Organ SystemsNeurologyHeadache DisordersMigraine, cluster, tension, raised ICP
11018 Oct 2026Organ SystemsNeurologyMultiple SclerosisPathophysiology, McDonald criteria, types, treatment
11119 Oct 2026Organ SystemsNeurologyPeripheral NeuropathyAxonal vs demyelinating, Guillain-Barré, Charcot-Marie-Tooth
11220 Oct 2026Organ SystemsNeurologyNeuromuscular Junction DisordersMyasthenia gravis, Lambert-Eaton, botulism
11321 Oct 2026Organ SystemsNeurologyCNS InfectionsMeningitis, encephalitis, brain abscess, CSF analysis
11422 Oct 2026Organ SystemsNeurologyCNS TumoursGlioblastoma, meningioma, acoustic neuroma, metastases
11523 Oct 2026Organ SystemsNeurologyNeuropharmacology — AnaestheticsLocal, general, neuromuscular blockers
11624 Oct 2026Organ SystemsNeurologyNeuropharmacology — AntiepilepticsMechanisms, teratogenicity, drug interactions
11725 Oct 2026Organ SystemsNeurologyNeuropharmacology — Parkinson's & MSLevodopa, dopamine agonists, interferons, natalizumab
11826 Oct 2026Organ SystemsNeurologyAutonomic Nervous SystemSympathetic vs parasympathetic, pharmacological targets
11927 Oct 2026Organ SystemsNeurologyPain Pathways & AnalgesicsAscending pain, opioids, NSAIDs, neuropathic pain
12028 Oct 2026Organ SystemsNeurologyNeurology Cases & IntegrationClinical vignette practice
12129 Oct 2026Organ SystemsGIGI EmbryologyGut tube formation, rotation, Meckel's diverticulum
12230 Oct 2026Organ SystemsGIOesophagusAchalasia, GERD, Barrett's, oesophageal cancer
12331 Oct 2026Organ SystemsGIStomach — PhysiologyGastric acid, parietal cells, gastrin, intrinsic factor
12401 Nov 2026Organ SystemsGIPeptic Ulcer DiseaseH. pylori, NSAIDs, Zollinger-Ellison, complications
12502 Nov 2026Organ SystemsGISmall Intestine — AbsorptionNutrients, vitamins, fat malabsorption, brush border enzymes
12603 Nov 2026Organ SystemsGIMalabsorption SyndromesCoeliac disease, Crohn's, tropical sprue, Whipple's
12704 Nov 2026Organ SystemsGIInflammatory Bowel Disease — Crohn'sSkip lesions, transmural, extraintestinal manifestations
12805 Nov 2026Organ SystemsGIInflammatory Bowel Disease — UCContinuous, mucosal, toxic megacolon, cancer risk
12906 Nov 2026Organ SystemsGIColorectal CancerAdenoma-carcinoma sequence, FAP, Lynch, staging
13007 Nov 2026Organ SystemsGIGI BleedingUpper vs lower, causes, management priorities
13108 Nov 2026Organ SystemsGILiver — PhysiologyBilirubin metabolism, liver function tests interpretation
13209 Nov 2026Organ SystemsGIHepatitis — ViralHep A, B, C, D, E — transmission, serology, chronicity
13310 Nov 2026Organ SystemsGIAlcoholic Liver DiseaseFatty liver, hepatitis, cirrhosis — histology and biomarkers
13411 Nov 2026Organ SystemsGICirrhosis & Portal HypertensionComplications — varices, ascites, HRS, SBP, HE
13512 Nov 2026Organ SystemsGILiver TumoursHCC, cholangiocarcinoma, metastases, haemangioma
13613 Nov 2026Organ SystemsGIMetabolic Liver DiseaseNAFLD, haemochromatosis, Wilson's, alpha-1 antitrypsin
13714 Nov 2026Organ SystemsGIGallbladder & BiliaryCholelithiasis, cholecystitis, cholangitis, PSC, PBC
13815 Nov 2026Organ SystemsGIPancreasAcute vs chronic pancreatitis, pancreatic cancer, cysts
13916 Nov 2026Organ SystemsGIGI PharmacologyPPIs, H2 blockers, antiemetics, laxatives, antidiarrhoeals
14017 Nov 2026Organ SystemsGIGI Cases & IntegrationClinical vignette practice
14118 Nov 2026Organ SystemsEndocrinologyHypothalamic-Pituitary AxisFeedback loops, releasing hormones, portal circulation
14219 Nov 2026Organ SystemsEndocrinologyAnterior PituitaryGH, prolactin, TSH, ACTH, FSH, LH — disorders
14320 Nov 2026Organ SystemsEndocrinologyPosterior PituitaryADH, oxytocin, diabetes insipidus, SIADH
14421 Nov 2026Organ SystemsEndocrinologyThyroid — PhysiologyT3/T4 synthesis, transport, peripheral conversion, feedback
14522 Nov 2026Organ SystemsEndocrinologyHypothyroidismHashimoto's, iodine deficiency, iatrogenic, myxoedema coma
14623 Nov 2026Organ SystemsEndocrinologyHyperthyroidismGraves', toxic nodule, thyroiditis, thyroid storm
14724 Nov 2026Organ SystemsEndocrinologyThyroid CancerPapillary, follicular, medullary, anaplastic — features
14825 Nov 2026Organ SystemsEndocrinologyAdrenal Cortex — PhysiologyZona glomerulosa, fasciculata, reticularis — steroidogenesis
14926 Nov 2026Organ SystemsEndocrinologyGlucocorticoid BiologyCortisol synthesis, stress response, receptor signalling
15027 Nov 2026Organ SystemsEndocrinologyAdrenal InsufficiencyPrimary vs secondary, Addison's, adrenal crisis
15128 Nov 2026Organ SystemsEndocrinologyCushing's SyndromeACTH dependent vs independent, dexamethasone suppression
15229 Nov 2026Organ SystemsEndocrinologyAdrenal Medulla & PhaeochromocytomaCatecholamine synthesis, VMA, metanephrines
15330 Nov 2026Organ SystemsEndocrinologyCongenital Adrenal Hyperplasia21-hydroxylase deficiency, salt-wasting, virilisation
15401 Dec 2026Organ SystemsEndocrinologyDiabetes Mellitus — Type 1Autoimmune destruction, DKA, insulin types
15502 Dec 2026Organ SystemsEndocrinologyDiabetes Mellitus — Type 2Insulin resistance, metabolic syndrome, HHS
15603 Dec 2026Organ SystemsEndocrinologyDiabetes PharmacologyMetformin, sulfonylureas, GLP-1, SGLT2, insulin
15704 Dec 2026Organ SystemsEndocrinologyCalcium & PTHHypo and hypercalcaemia, PTH, PTHrP, vitamin D
15805 Dec 2026Organ SystemsEndocrinologyParathyroid DisordersPrimary, secondary, tertiary hyperPTH, hypoparathyroidism
15906 Dec 2026Organ SystemsEndocrinologyMEN SyndromesMEN1, MEN2A, MEN2B — tumour associations
16007 Dec 2026Organ SystemsEndocrinologyEndocrinology Cases & IntegrationClinical vignette practice
16108 Dec 2026Organ SystemsHaematologyHaematopoiesisStem cells, lineages, growth factors, bone marrow
16209 Dec 2026Organ SystemsHaematologyAnaemia — Overview & Iron DeficiencyClassification, indices, iron studies, iron deficiency anaemia
16310 Dec 2026Organ SystemsHaematologyAnaemia — B12 & FolateMegaloblastic anaemia, subacute combined degeneration
16411 Dec 2026Organ SystemsHaematologyHaemolytic AnaemiaIntrinsic vs extrinsic, Coombs test, sickle cell, spherocytosis
16512 Dec 2026Organ SystemsHaematologySickle Cell DiseasePathophysiology, crises, complications, management
16613 Dec 2026Organ SystemsHaematologyThalassaemiaAlpha vs beta, genetics, transfusion dependency
16714 Dec 2026Organ SystemsHaematologyEnzyme Deficiencies & RBC MembraneG6PD, PK deficiency, hereditary spherocytosis, elliptocytosis
16815 Dec 2026Organ SystemsHaematologyPlatelet DisordersITP, TTP, HUS, thrombocytopenia — causes and management
16916 Dec 2026Organ SystemsHaematologyCoagulation CascadeIntrinsic vs extrinsic, PT vs aPTT, factor deficiencies
17017 Dec 2026Organ SystemsHaematologyCoagulation DisordersHaemophilia A and B, von Willebrand disease, DIC
17118 Dec 2026Organ SystemsHaematologyThrombophiliaFactor V Leiden, protein C/S deficiency, antiphospholipid
17219 Dec 2026Organ SystemsHaematologyLeukaemia — ALL & CLLAge predilection, markers, prognosis, Philadelphia chromosome
17320 Dec 2026Organ SystemsHaematologyLeukaemia — AML & CMLFAB classification, Auer rods, BCR-ABL, imatinib
17421 Dec 2026Organ SystemsHaematologyLymphoma — Hodgkin'sReed-Sternberg cells, subtypes, staging, EBV
17522 Dec 2026Organ SystemsHaematologyLymphoma — Non-Hodgkin'sDiffuse large B cell, Burkitt's, follicular, mantle cell
17623 Dec 2026Organ SystemsHaematologyMultiple MyelomaPlasma cell dyscrasia, CRAB criteria, M spike, treatment
17724 Dec 2026Organ SystemsHaematologyMyeloproliferative DisordersPolycythaemia vera, ET, myelofibrosis, JAK2
17825 Dec 2026Organ SystemsHaematologyCancer BiologyHallmarks of cancer, oncogenesis, metastasis cascade
17926 Dec 2026Organ SystemsHaematologyCancer Pharmacology — ChemotherapyAlkylating agents, antimetabolites, topoisomerase inhibitors
18027 Dec 2026Organ SystemsHaematologyCancer Pharmacology — Targeted & ImmunotherapyTyrosine kinase inhibitors, checkpoint inhibitors, CAR-T
18128 Dec 2026Organ SystemsHaematologyHaematology Cases & IntegrationClinical vignette practice
18229 Dec 2026Organ SystemsMSKBone PhysiologyOsteoblasts, osteoclasts, bone remodelling, calcium regulation
18330 Dec 2026Organ SystemsMSKOsteoporosis & Paget's DiseaseDEXA, bisphosphonates, Paget's — pathophysiology
18431 Dec 2026Organ SystemsMSKBone TumoursOsteosarcoma, Ewing's, chondrosarcoma, giant cell tumour
18501 Jan 2027Organ SystemsMSKRheumatoid ArthritisPathophysiology, extraarticular, anti-CCP, treatment
18602 Jan 2027Organ SystemsMSKSeronegative SpondyloarthropathiesAnkylosing spondylitis, psoriatic arthritis, reactive arthritis
18703 Jan 2027Organ SystemsMSKCrystal ArthropathiesGout, pseudogout, urate metabolism, colchicine
18804 Jan 2027Organ SystemsMSKOsteoarthritisPathophysiology, joints affected, Heberden vs Bouchard nodes
18905 Jan 2027Organ SystemsMSKSystemic Lupus ErythematosusCriteria, ANA, anti-dsDNA, lupus nephritis, drug-induced
19006 Jan 2027Organ SystemsMSKMyositis & SclerodermaDM, PM, CREST syndrome, anti-Scl-70, anti-centromere
19107 Jan 2027Organ SystemsMSKVasculitis — Large VesselGCA, Takayasu's — presentations and treatment
19208 Jan 2027Organ SystemsMSKVasculitis — Small & Medium VesselGPA, MPA, EGPA, PAN, Kawasaki, Henoch-Schönlein
19309 Jan 2027Organ SystemsMSKMSK PharmacologyDMARDs, biologics, NSAIDs, corticosteroids in rheum
19410 Jan 2027Organ SystemsMSKMuscle PhysiologySarcomere, sliding filament, neuromuscular junction
19511 Jan 2027Organ SystemsMSKMSK Cases & IntegrationClinical vignette practice
19612 Jan 2027Organ SystemsDermatologySkin Structure & FunctionEpidermis layers, dermis, appendages, skin barrier
19713 Jan 2027Organ SystemsDermatologyCommon Inflammatory DermatosesPsoriasis, eczema, contact dermatitis, seborrhoeic
19814 Jan 2027Organ SystemsDermatologyBlistering DisordersPemphigus vulgaris, bullous pemphigoid, dermatitis herpetiformis
19915 Jan 2027Organ SystemsDermatologySkin CancerBCC, SCC, melanoma — ABCDE, risk factors, spread
20016 Jan 2027Organ SystemsDermatologyInfectious DermatologyCellulitis, impetigo, tinea, herpes zoster, SSSS
20117 Jan 2027Organ SystemsDermatologySystemic Disease & SkinSkin findings in diabetes, SLE, liver disease, sarcoid
20218 Jan 2027Organ SystemsDermatologyDermatology Cases & IntegrationClinical vignette practice
20319 Jan 2027Organ SystemsReproductiveReproductive EmbryologyGenital development, Müllerian/Wolffian ducts, intersex
20420 Jan 2027Organ SystemsReproductiveFemale Reproductive PhysiologyMenstrual cycle, ovarian and uterine phases, hormones
20521 Jan 2027Organ SystemsReproductiveMale Reproductive PhysiologySpermatogenesis, testosterone, FSH/LH axis
20622 Jan 2027Organ SystemsReproductiveContraception & InfertilityOCP mechanism, IUD, emergency contraception, infertility workup
20723 Jan 2027Organ SystemsReproductiveSTIsGonorrhoea, chlamydia, syphilis, herpes, HPV, HIV
20824 Jan 2027Organ SystemsReproductiveNormal Pregnancy & ObstetricsPhysiological changes, prenatal screening, labour
20925 Jan 2027Organ SystemsReproductiveObstetric ComplicationsPre-eclampsia, eclampsia, placenta praevia, abruption
21026 Jan 2027Organ SystemsReproductiveGynaecological PathologyEndometriosis, fibroids, PCOS, ovarian cysts
21127 Jan 2027Organ SystemsReproductiveGynaecological CancerCervical, endometrial, ovarian cancer — risk factors and screening
21228 Jan 2027Organ SystemsReproductiveBreast PathologyFibrocystic changes, fibroadenoma, breast cancer — types
21329 Jan 2027Organ SystemsReproductiveReproductive PharmacologyOxytocin, tocolytics, fertility drugs, antiandrogens
21430 Jan 2027Organ SystemsReproductiveReproductive Cases & IntegrationClinical vignette practice
21531 Jan 2027Organ SystemsPsychiatryPsychiatric Epidemiology & DSMPrevalence, diagnostic framework, biopsychosocial model
21601 Feb 2027Organ SystemsPsychiatryPsychotic DisordersSchizophrenia — positive/negative symptoms, dopamine hypothesis
21702 Feb 2027Organ SystemsPsychiatryMood Disorders — DepressionMDD, dysthymia, postpartum, atypical features
21803 Feb 2027Organ SystemsPsychiatryMood Disorders — BipolarBipolar I vs II, cyclothymia, rapid cycling
21904 Feb 2027Organ SystemsPsychiatryAnxiety DisordersGAD, panic disorder, phobias, PTSD, OCD
22005 Feb 2027Organ SystemsPsychiatryPersonality DisordersClusters A, B, C — key features for USMLE
22106 Feb 2027Organ SystemsPsychiatrySomatoform DisordersSomatic symptom disorder, conversion, factitious, malingering
22207 Feb 2027Organ SystemsPsychiatryEating DisordersAnorexia vs bulimia — complications and medical management
22308 Feb 2027Organ SystemsPsychiatrySubstance Use DisordersAlcohol, opioids, stimulants — intoxication, withdrawal, treatment
22409 Feb 2027Organ SystemsPsychiatryChild & Developmental PsychiatryADHD, autism, conduct disorder, childhood depression
22510 Feb 2027Organ SystemsPsychiatryAntidepressantsSSRIs, SNRIs, TCAs, MAOIs — mechanisms and side effects
22611 Feb 2027Organ SystemsPsychiatryAntipsychoticsTypical vs atypical, EPS, NMS, metabolic syndrome
22712 Feb 2027Organ SystemsPsychiatryMood Stabilisers & AnxiolyticsLithium toxicity, valproate, benzodiazepines
22813 Feb 2027Organ SystemsPsychiatryPsychiatry Cases & IntegrationClinical vignette practice
22914 Feb 2027Organ SystemsInfectious DiseaseGram Positive CocciStaph aureus, strep pneumo, strep pyogenes — virulence and disease
23015 Feb 2027Organ SystemsInfectious DiseaseGram Negative Rods — EntericE. coli, Salmonella, Shigella, Campylobacter, H. pylori
23116 Feb 2027Organ SystemsInfectious DiseaseGram Negative Rods — RespiratoryHaemophilus, Klebsiella, Pseudomonas, Legionella, Bordetella
23217 Feb 2027Organ SystemsInfectious DiseaseAnaerobes & SpirochaetesClostridium, Bacteroides, Treponema, Leptospira, Borrelia
23318 Feb 2027Organ SystemsInfectious DiseaseIntracellular OrganismsRickettsia, Chlamydia, Mycoplasma, Coxiella — atypical pneumonia
23419 Feb 2027Organ SystemsInfectious DiseaseFungiCandida, Aspergillus, Cryptococcus, Histoplasma, Coccidioides
23520 Feb 2027Organ SystemsInfectious DiseaseParasites — ProtozoaMalaria, Toxoplasma, Giardia, Cryptosporidium, Entamoeba
23621 Feb 2027Organ SystemsInfectious DiseaseParasites — HelminthsRoundworms, tapeworms, flukes — key species
23722 Feb 2027Organ SystemsInfectious DiseaseHIV & AIDSLife cycle, CD4 staging, opportunistic infections, ART
23823 Feb 2027Organ SystemsInfectious DiseaseDNA VirusesHerpes family, adenovirus, parvovirus, HPV, HBV
23924 Feb 2027Organ SystemsInfectious DiseaseRNA VirusesInfluenza, HIV, measles, mumps, rubella, rabies, Ebola
24025 Feb 2027Organ SystemsInfectious DiseaseAntibiotics — Cell WallPenicillins, cephalosporins, carbapenems, vancomycin
24126 Feb 2027Organ SystemsInfectious DiseaseAntibiotics — Protein SynthesisAminoglycosides, macrolides, tetracyclines, chloramphenicol
24227 Feb 2027Organ SystemsInfectious DiseaseAntivirals, Antifungals & AntiparasiticsAciclovir, oseltamivir, azoles, amphotericin, chloroquine
24328 Feb 2027Organ SystemsInfectious DiseaseSepsis & BacteraemiaSIRS criteria, source control, empirical antibiotics
24401 Mar 2027Organ SystemsInfectious DiseaseInfectious Disease CasesClinical vignette practice
24502 Mar 2027Organ SystemsImmunologyT Cell BiologyCD4 vs CD8, Th1/Th2/Th17/Treg, activation, tolerance
24603 Mar 2027Organ SystemsImmunologyB Cell Biology & AntibodiesB cell activation, class switching, antibody types
24704 Mar 2027Organ SystemsImmunologyComplement SystemClassical, lectin, alternative pathways — C3, C5, MAC
24805 Mar 2027Organ SystemsImmunologyPrimary Immunodeficiencies — B CellBruton's, common variable, selective IgA deficiency
24906 Mar 2027Organ SystemsImmunologyPrimary Immunodeficiencies — T Cell & CombinedDiGeorge, SCID, Wiskott-Aldrich, ataxia telangiectasia
25007 Mar 2027Organ SystemsImmunologyHypersensitivity ReactionsType I-IV, mechanisms, clinical examples
25108 Mar 2027Organ SystemsImmunologyTransplant ImmunologyHLA matching, rejection types, graft vs host disease
25209 Mar 2027Organ SystemsImmunologyImmunosuppressantsCiclosporin, tacrolimus, azathioprine, mycophenolate, biologics
25310 Mar 2027Organ SystemsImmunologyVaccinesLive attenuated vs killed, mRNA, schedule, contraindications
25411 Mar 2027Organ SystemsImmunologyImmunology Cases & IntegrationClinical vignette practice
25512 Mar 2027IntegrationBiostatisticsStudy DesignRCT, cohort, case-control, cross-sectional — strengths and biases
25613 Mar 2027IntegrationBiostatisticsBias & ConfoundingSelection, recall, lead time bias, confounders, randomisation
25714 Mar 2027IntegrationBiostatisticsStatistical Testst-test, chi-squared, ANOVA, regression — when to use which
25815 Mar 2027IntegrationBiostatisticsSensitivity, Specificity & Predictive Values2x2 table, ROC curves, likelihood ratios
25916 Mar 2027IntegrationBiostatisticsScreening & PreventionPrimary, secondary, tertiary prevention, NNT, NNH
26017 Mar 2027IntegrationBiostatisticsEpidemiologyIncidence vs prevalence, mortality measures, outbreak investigation
26118 Mar 2027IntegrationBiostatisticsBiostatistics Cases & IntegrationPractice calculations and vignettes
26219 Mar 2027IntegrationEthicsMedical Ethics PrinciplesAutonomy, beneficence, non-maleficence, justice
26320 Mar 2027IntegrationEthicsInformed ConsentCapacity, competence, surrogate decision making
26421 Mar 2027IntegrationEthicsConfidentiality & DisclosureExceptions, duty to warn, mandatory reporting
26522 Mar 2027IntegrationEthicsEnd of Life EthicsDNR, withdrawal of care, euthanasia vs assisted dying
26623 Mar 2027IntegrationEthicsResearch EthicsTuskegee, Helsinki, IRB, equipoise
26724 Mar 2027IntegrationPharmacologyPharmacokineticsADME, volume of distribution, half-life, bioavailability
26825 Mar 2027IntegrationPharmacologyPharmacodynamicsReceptor types, agonism, antagonism, dose-response curves
26926 Mar 2027IntegrationPharmacologyAutonomic PharmacologyAdrenergic and cholinergic drugs — clinical applications
27027 Mar 2027IntegrationPharmacologyHigh Yield Drug ToxicitiesAminoglycosides, cisplatin, methotrexate, amiodarone
27128 Mar 2027IntegrationPharmacologyDrug InteractionsCYP450 inducers and inhibitors, warfarin interactions
27229 Mar 2027IntegrationPharmacologyHigh Yield AntidotesN-acetylcysteine, naloxone, atropine, flumazenil
27330 Mar 2027IntegrationPharmacologyPharmacology CasesClinical vignette practice — drug identification
27431 Mar 2027IntegrationPathologyCell Injury & DeathNecrosis types, apoptosis, ischaemia, free radicals
27501 Apr 2027IntegrationPathologyInflammationAcute vs chronic, granulomas, wound healing
27602 Apr 2027IntegrationPathologyNeoplasiaBenign vs malignant, invasion, metastasis, tumour markers
27703 Apr 2027IntegrationPathologyHaemodynamicsOedema, hyperaemia, thrombosis, embolism, infarction
27804 Apr 2027IntegrationPathologyGenetic & Congenital PathologyChromosomal, single gene, multifactorial disorders
27905 Apr 2027IntegrationPathologyEnvironmental & Nutritional PathologyToxins, radiation, nutritional deficiencies
28006 Apr 2027IntegrationPathologyPathology Integration ReviewCross-system pathology cases
28107 Apr 2027Exam PrepIntegrationComplex Cardio-Renal CasesCardiorenal syndrome, diuretic resistance
28208 Apr 2027Exam PrepIntegrationNeuro-Psych IntegrationOrganic vs psychiatric, delirium vs dementia vs depression
28309 Apr 2027Exam PrepIntegrationEndocrine-Renal CasesDiabetes and kidney, hyperaldosteronism, renal tubular syndromes
28410 Apr 2027Exam PrepIntegrationHaem-Onc Complex CasesParaneoplastic syndromes, tumour lysis, hypercoagulability
28511 Apr 2027Exam PrepIntegrationGI-Liver-Pancreas CasesAcute abdomen, jaundice workup, hepatorenal syndrome
28612 Apr 2027Exam PrepIntegrationImmunology-Infection CasesImmunocompromised host, transplant infections
28713 Apr 2027Exam PrepIntegrationReproductive-Endocrine CasesPCOS, thyroid in pregnancy, gestational diabetes
28814 Apr 2027Exam PrepIntegrationRespiratory-Cardiac CasesCor pulmonale, PE mimicking MI, respiratory failure
28915 Apr 2027Exam PrepIntegrationMSK-Neuro CasesMotor neuron disease, myopathy vs neuropathy
29016 Apr 2027Exam PrepIntegrationDermatology-Systemic CasesRashes in systemic disease, drug reactions
29117 Apr 2027Exam PrepPathologyHigh Yield Histology — Cardio & RespiratoryMI, cardiomyopathy, pneumonia, fibrosis slides
29218 Apr 2027Exam PrepPathologyHigh Yield Histology — GI & LiverCirrhosis, IBD, colon cancer, hepatitis slides
29319 Apr 2027Exam PrepPathologyHigh Yield Histology — Renal & EndocrineGlomerulonephritis, RCC, thyroid, adrenal slides
29420 Apr 2027Exam PrepPathologyHigh Yield Histology — Haem & NeuroLeukaemia, lymphoma, glioma, MS slides
29521 Apr 2027Exam PrepPathologyHigh Yield RadiologyCXR, CT findings, X-ray patterns for USMLE
29622 Apr 2027Exam PrepPathologyHigh Yield ECG ReviewMost tested ECG patterns — STEMI, blocks, arrhythmias
29723 Apr 2027Exam PrepPathologyHigh Yield Lab ValuesElectrolyte patterns, anaemia workup, LFTs, coagulation
29824 Apr 2027Exam PrepReviewRapid Fire — BiochemistryHighest yield facts, classic vignettes
29925 Apr 2027Exam PrepReviewRapid Fire — MicrobiologyOrganisms, virulence, drug of choice
30026 Apr 2027Exam PrepReviewRapid Fire — CardiologyClassic presentations, drugs, ECG findings
30127 Apr 2027Exam PrepReviewRapid Fire — RespiratoryClassic presentations, PFTs, drugs
30228 Apr 2027Exam PrepReviewRapid Fire — RenalElectrolytes, acid-base, drugs
30329 Apr 2027Exam PrepReviewRapid Fire — NeurologyLocalisation, strokes, drugs
30430 Apr 2027Exam PrepReviewRapid Fire — GIClassic cases, liver disease, cancer
30501 May 2027Exam PrepReviewRapid Fire — EndocrinologyHormones, feedback loops, drugs
30602 May 2027Exam PrepReviewRapid Fire — HaematologyAnaemia, coagulation, cancers
30703 May 2027Exam PrepReviewRapid Fire — MSK & DermJoint diseases, rashes, drugs
30804 May 2027Exam PrepReviewRapid Fire — PsychiatryDisorders, drugs, ethics
30905 May 2027Exam PrepReviewRapid Fire — Infectious DiseaseOrganisms, antibiotics, HIV
31006 May 2027Exam PrepReviewRapid Fire — ImmunologyDeficiencies, hypersensitivity, transplant
31107 May 2027Exam PrepReviewRapid Fire — PharmacologyMechanisms, toxicities, antidotes
31208 May 2027Exam PrepBridgeUK vs US Medical EducationGMC vs USMLE, BM BCh vs MD, training pathways
31309 May 2027Exam PrepBridgeIMG Application StrategyERAS, USMLE scores, research, LORs, visa
31410 May 2027Exam PrepBridgeStep 1 Exam StrategyTiming, question approach, educated guessing
31511 May 2027Exam PrepBridgeStep 2 CK PreviewHow Step 2 differs, clinical vignettes, preparation timeline
31612 May 2027Exam PrepBridgeResources ReviewFirst Aid, UWorld, Anki, Sketchy, Pathoma — how to use each
31713 May 2027Exam PrepFinal ReviewCardiology Final ReviewMost tested topics, classic mistakes
31814 May 2027Exam PrepFinal ReviewRespiratory Final ReviewMost tested topics, classic mistakes
31915 May 2027Exam PrepFinal ReviewRenal Final ReviewMost tested topics, classic mistakes
32016 May 2027Exam PrepFinal ReviewNeurology Final ReviewMost tested topics, classic mistakes
32117 May 2027Exam PrepFinal ReviewGI Final ReviewMost tested topics, classic mistakes
32218 May 2027Exam PrepFinal ReviewEndocrinology Final ReviewMost tested topics, classic mistakes
32319 May 2027Exam PrepFinal ReviewHaematology Final ReviewMost tested topics, classic mistakes
32420 May 2027Exam PrepFinal ReviewMSK Final ReviewMost tested topics, classic mistakes
32521 May 2027Exam PrepFinal ReviewPsychiatry Final ReviewMost tested topics, classic mistakes
32622 May 2027Exam PrepFinal ReviewID & Immunology Final ReviewMost tested topics, classic mistakes
32723 May 2027Exam PrepFinal ReviewBiochemistry & Genetics Final ReviewMost tested topics, classic mistakes
32824 May 2027Exam PrepFinal ReviewPharmacology Final ReviewMost tested topics, classic mistakes
32925 May 2027Exam PrepFinal ReviewBiostatistics & Ethics Final ReviewMost tested topics, classic mistakes
33026 May 2027Exam PrepFinal ReviewNBME Practice Exam WalkthroughLive question analysis and strategy
33127 May 2027BonusCommunityQ&A — BiochemistryAudience questions answered live
33228 May 2027BonusCommunityQ&A — CardiologyAudience questions answered live
33329 May 2027BonusCommunityQ&A — NeurologyAudience questions answered live
33430 May 2027BonusCommunityQ&A — Renal & EndocrineAudience questions answered live
33531 May 2027BonusCommunityQ&A — GI & HepatologyAudience questions answered live
33601 Jun 2027BonusCommunityQ&A — Haematology & OncologyAudience questions answered live
33702 Jun 2027BonusCommunityQ&A — ID & ImmunologyAudience questions answered live
33803 Jun 2027BonusCommunityQ&A — Psychiatry & EthicsAudience questions answered live
33904 Jun 2027BonusCommunityQ&A — PharmacologyAudience questions answered live
34005 Jun 2027BonusCommunityQ&A — BiostatisticsAudience questions answered live
34106 Jun 2027BonusSpecialInterview — US Residency ApplicantReal IMG who matched at a top US programme
34207 Jun 2027BonusSpecialInterview — Mayo Clinic PhysicianWhat they look for in IMG applicants
34308 Jun 2027BonusSpecialInterview — Step 1 High Scorer260+ scorer shares their strategy
34409 Jun 2027BonusSpecialOxford Medicine ExplainedFHS, BM BCh, how it compares to US MD
34510 Jun 2027BonusSpecialUK Clinical Years Survival GuideHow to balance USMLE prep with UK clinical training
34611 Jun 2027BonusSpecialMyUSMLE Community ShowcaseBest student questions, community highlights
34712 Jun 2027BonusSpecialMedtech & Clinical MedicineHow clinical knowledge drives innovation
34813 Jun 2027BonusSpecialResearch for IMG ApplicantsHow to get research as a UK student
34914 Jun 2027BonusSpecialMental Health in MedicineBurnout, wellbeing, sustainable study
35015 Jun 2027BonusSpecialStep 2 CK Preview — MedicineIntroduction to Step 2 approach
35116 Jun 2027BonusSpecialStep 2 CK Preview — SurgerySurgical principles for Step 2
35217 Jun 2027BonusSpecialStep 2 CK Preview — PaediatricsPaediatric medicine for Step 2
35318 Jun 2027BonusSpecialStep 2 CK Preview — OB/GYNObstetrics for Step 2
35419 Jun 2027BonusSpecialStep 2 CK Preview — PsychiatryPsychiatry on Step 2 vs Step 1
35520 Jun 2027BonusSpecialStep 2 CK Preview — Emergency MedicineEM approach for Step 2
35621 Jun 2027BonusSpecialUS Residency Application Deep Dive — ERASCompleting ERAS as an IMG
35722 Jun 2027BonusSpecialPersonal Statement WorkshopCrafting a compelling IMG personal statement
35823 Jun 2027BonusSpecialLetters of Recommendation GuideWho to ask, how to ask, what makes a great LOR
35924 Jun 2027BonusSpecialInterview PreparationUS residency interview common questions
36025 Jun 2027BonusSpecialMatch Day ExplainedNRMP algorithm, ranking strategies
36126 Jun 2027BonusSpecialSeries Reflection — Year 1What we learned, what worked, what's next
36227 Jun 2027BonusSpecialMyUSMLE Future PlansStep 2 series, community growth, partnerships
36328 Jun 2027BonusSpecialThank You & CommunityCelebrating the journey together
36429 Jun 2027BonusSpecialFinal Exam Pep TalkMotivation and mindset for exam day
36530 Jun 2027BonusSpecialDay 365 — What Comes NextStep 2, residency, the future of MyUSMLE

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